TABLET EVALUATION

MEMORIZER

TABLET EVALUATION

1 Size & thickness = -/+ 5 %

2 UNique identification marking,

3 Organoleptic marking = colour ,taste , odour apperance

COLOUR measured by

a reflectance spectrometer
b tristimulus colorimetery
c micro reflectancemeter

4 Hardness & Friability hardness instrument...a mosanto tester
b erweka tester
c strong & cobb tester
d schleuniger
e pfizer

Friability = 0.5 - 1 % roche friabilator

5 weight variation ....20 tab are tested acc to USP NMT 2 outside the limit

NMT 2 times of the % limit.

acc to IP less then 85mg +/_ 10%
85mg-250mg +/_ 7.5%
greater than 250mg +/_ 5%

6 Disintegration temp 37+/_ 2 C
6 tubes 3 inch long 10 mesh size

28-32 cycles /min

uncoated =5 min , coated = 30min

enteric in gastric like fluid no sign of disintegration in 1 hr

& in intestinal like fluid 2hrs plus moograph value

7 dissolution test...