Wednesday, 16 May 2012

NIPER JEE- 2011


NIPER  JEE- 2011
sequence of steps involved in the PCR??
denaturation,anealing and ___
Bond strenth order in case of C-H,C-c,H-H,C-Cl
in which of the following ,nucleophilic substitution take place through benzyne formation
a.nitro benzene b.picric acid c.p-methoxy nitro benzene d.____
Ad:Be:Cr:??? (something like that) ans was Dx
shape of vasaka leaf??
lanceolate, obovate
which of the following is from marine source
a.protamine b.pralidoxime c.both d. none
drug acting on translocation step??? macrolide
drug binding to 30s site??? TC
equation used for calculation of buffers pH is ?
drug which increases QT interval prolongation?
Vd calculation.
which of the following drug is used in treatment of diarrhoea?
D-glyceraldehyde configuration??
which is more basic? pyrole, aniline, pyridine, N,N dimethylaniline?
units for molar extinction coefficient
which of the following Immunoglobulin activates complement system??
a. IgG b.IgM c.IgD d.IgE
which of the following Immunoglobulin is responsible for allergic reaction???
which of the following Immunoglobulin is used as solubilizer for Vit A and???
a. peg b.peg and lanolin ester (not exactly remember)
type of instrumentation used for quantitative analysis?GC UV NMR IR
A man completes some distance in 8 hrs. He travels first half at 40 KPH and rest at 60 KPH.
What is the total distance covered?
precursor of psoraline?
mitochondria is involved in ..... a. fat production b) glu production c) electron
transport...
CAP is used as an enteric material. It solubilises at (a) 2.5 (b) 4.5 (c) 5.5
Who coined the term Pharmacognosy?
h.pylori cause?
tonicity adjustifier used in parentrals?
which is not a brand of Dabur? Glucose D, odomos, nihar,meswak
imit test appratus for arsenic? nesselers cylinder , kjeldahls app. , kipps app....gutzeit
app...
agaro pectin agar contains?glu.uronic acid..
the following one is nt a disaccharide
glucopyranose matltose sucrose lactose
Antioxidant wid red.agent property?
Tocopherol,thiourea,
which tissue comes to d equlibrium first
a.heart b.liver c. fat d. brain
glycolysis occurs in?cytosol
which type if reaction occurs more in water than in d2o
a.sn1 b. sn2 c.elimination d. none
schedule deals with disinfectants ? ans schedule o
wich form of drug is more absorbable? ans: unionized
ion form of drug is more seen in
a.urine b. blood c. serum d.......
ph of blood is???????? 7.4
wet granulation is nt done by
a.roller compactor b.planetary mixer c............
the use of sodium saccharin in parentrals
a.sweetner b. solubuliser c. bulking agent d.stabilizer
rhubarb used as?
a.sweetner b. purgative c. bitter d.carminative
SN2 reaction is??
Inversion f cnfiguration
Cycloaddition by??
Diels alder reaction
+nt BCCI chief?
Sashank manohar
Brand endorsed by sania mirza?
Complain,boost,horlicks,bournv
ita
dry powder type of injections r prepared by
a.dry heat sterilization b. autoclaving c. aseptic filling d. gas sterilization
preservative used in opthalmic solutions
a.benzalkonium chloride b. chloro cresol
condensed tannins r
a.cynadins b. procynadins c.proanthocyanidins
ADH harmone regulates
a.blood glucose b. serum calcium level c. urine conc d. all
pharmacy council of india is formed by?
a. cenral gov b. assembly c. parliament d. state gov
gossypol shows chirality because of?
a.chirality of carbon b. chirality of nitrogen c. restriction of rotation
what is d annual income of country?
morphine was discovered in?
a.1804 b. 1904 c. 1920 c. 1820
sabsidi means?
3rd gen sulpha anti diabetic drug
a.gimpride b. phenformin c. metformin d. repaglinide
drug used in the preterm delivery?oxytocin ,sulfoprostone,atosiban,
the anti tubuculor drug that does nt show hepatotoxicity?
a.rifampicin b.ethionamide c. pyrazinamide d. streptomycin
mayers reagent is?
songs of sword nd blood: a daughters memoir is written by?? 1.fatima bhuto 2.priyanka
gandhi
in eng knowledge audacious means?,
magnanimus mmeans?
rebate means?
graphic means??
limit test of arsenic is conducted in______ apparatus
Mannitol used in chewable tablet because of wich property? ans: negative heat of solution
optical rotation can be shown by
a.molecule b. crystal c. both d. none
salbutamol shows reduction in activity on prolonged usage because of?
a.receptor up regulation b. receptor down regulation c. receptor sensitization
a vehicle travels a distance in 8 hrs.if it travels 1st half at 40 km/hr n da rest at 60
km/hr.then wat is da total distance it travels?
wich of d folowing technique can transfer crystalline form into amorphous form?
a.spray drying b. freeze drying c. micronization d. non
what is d prodrug 4m below optins
a.aspirin b.sulphaselzine c. sulindac D.naproxen
dicalcium phosphate is not used as diluent in chewable tabs
most commonly used diluent in chewable tablets is mannitol
ultrashort actng barbiturate------thiopental sod
increase in lipase levels indicate which organ disfunction?
dna polymerase contains?3'-5' polymerase n 5'-3' exonuclease
wat is rspncbl 4 ir spctra ???chahge in dipole moment
wittig reaction??phosphorous.
antidote 4 heparin>???
IUPAC of propanolol
nature of s.phase nd mobile phase in reversed phase chromatography?
whts this Family of Bael?
cheif constituents of podophyllum?
whch of nt having hapetotoxicity 1. rifampicin 2.pyrizinamide 3. ethambutol 4.streptomycin
Platelets are synthesized 4m whch cells
IR Range 4 N-H strech?
vulconizing agent used in rubber?
highly permeable plastic polymer? polystyrene , nylon LDPA
which of the following polymer is not sterilized??
erythrose n therose r??? diastereomer
Kaya Skin clinic related to company????zydus
reliance overtook whch flying Unit or company, 1.kinfisher 2. deccan 3,jet airways
Kaolin is Purified....???
proof strength of h2o2 accng to Ip?
carbopols r?

Some very important topics for NIPER JEE

Some very important topics for NIPER JEE

• Ramachandran plot, HANz plot, structure of proteins,Docking
• Definition of software COMFA – MOLECULAR MECHANICS , MOLECULAR DYNAMICS
QSAR, HAMMETT EQUATION
• NAME REACTIONS
• MBA : PRIVATE FUND, BANK ACCOUNT,PUBLIC ACOUNT, CREDIT AND DEBT, MUTUAL FUND, number. of members in public, private and government company.Cooperative and joint sector,BSE & NSE
• STEREOCHEMISTRY : CHIRALITY, ASSYMETRIC ,DYSSMETRIC, ENANTIOMERS, DIASTEROMERS, D,L CONFIGRATION,ERYTHRO,AND THREO AND
• BASIC CONCEPT OF DNA AND RNA,PROTEIN ,LIPIDS
• ANALYTICAL CHEMISTRY: GRAPH OF THERMAL(DSC,DTA,TGA),POTENTIOMETRY, NMR –PROTON AND CARBON 13 NMR,IR ETC.
• BASIC CONCEPT OF CARBONYL CHEMSTRY INCLUDING NUCLEOPHILIC ADDITION, SINGLE ELECTRON TRANSFER, ENOLATE CHEMISTRY
• PHARMACY PRACTICE AND PHARMACOLOGY: CAUSITIVE ORGANISIM AND DRUGS USED FOR TREATMENT OF TUBERCULOSIS, LISHMANIASIS, MALARIA, DIABETES, DRUG INTERACTIONS DELAYED AND RAPID. INFECTIOUS DISEASES, NEWER DRUGS APPROVED IN 2009 AND DRUGS WITHDRAWN.REGULATORY BODIES IN INDIA, ( DR. Surinder singh )DCGI OF INDIA. CDSCO.CLINICAL TRIALS BASICS.visit WHO india AND ICH guidelines Full forms and www.whoindia.org,
• PHARMACEUTICS: superdisintegrants, liposomes, NDDS, IP USP regulations for coated tablet, plain tablet, chewable tabs- time taken to disintegrate. Tablets, capsules, aresols propellants.
• BIOTECHNOLOGY

Country – Capital – Currency


Country – Capital – Currency

France – Paris – France
Germany – Berlin – Deutsche Mar
Greece – Athens – Drachma
Hong Kong - Victoria – Dollar
India - New Delhi – Rupee
Indonesia - Jakarta – Rupiah
Iran - Teheran – Rial
Iraq - Baghdad – Dinar
Ireland – Dublin – Pound
Italy - Rome – Lira
Japan – Tokyo – Yen
Kenya - Nairobi – Shilling
Malaysia - Kuala Lumpur – Ringgit
Nepal – Kathmandu – Rupee
New Zealand - Wellington – Dollar
Oman - Muscat – Rial
Pakistan – Islamabad – Rupee
Qatar – Doha – Riyal
Russia - Moscow – Ruble
Saudi Arabia – Riyadh – Rial
Singapore – Singapore City – Dollar
South Africa - Madrid – Rand
Spain – Madrid – Peseta
Sri Lanka - Colombo – Rupee
Sweden - Stockholm – Krona
Switzerland – Berne – France
Russia – Moscow – Ruble
Ukraine – Kiev – Hyrvnia
Azerbaijan – Baku – Ruble
Thailand – Bangkok – Baht
United Arab Emirates (UAE) – Abu Dhabi – Dirham
United Kingdom (UK)-London – Pound Sterling
United States of America (US) -Washington – Dollar
Yemen – Sana – Rial
Zimbabwe -Harare – Dollar

GPAT 2012 Ans Key

IMP Years List


IMP Years List  :Useful for NIPER JEE

1935 RBI established
1949 RBI Nationalized
2005 RTI ACT
2005 Product Patent In India
1956 Companies Act
1932 Partnership Act
1993 End of GATT era
1997 National Pharmaceutical Pricing Authority (NPPA)
1994 Dolly sheep – First clone
1950 First Planning Commission
1984 Hatch-Waxman Act
1955 SBI nationalized
2005 IPC constituted
1896 First Olympics
2000 (26 Jan.) Human Genome Revealed
1970 Indian Patents Act
1919 Poison Act
1948 Pharmacy Act
1940 Drug and Cosmetic Act
1930 Dangerous Drug Act
1857 Opium Act
1954 Drug and Magic Remedies Act
1971 Medical Termination of Pregnancy Act
1989 First ICH
Indian pharmacopoeias:
1955- 1st Edition
1966- 2nd Edition
1985-3rd Edition
1996-4th Edition
2007-5th Edition
2010-6th Edition

NIPER JEE : What to READ ???



NIPER – What to READ???

Instructions:

§  Ø National Institute of Pharmaceutical Education and Research is the premier Institute in INDIA for pursuing the post graduation in Pharmaceutical line running in Mohali, Ahmedabad, Raibareilly, Kolkata, Hyderabad, Guwahati and Hajipur.
§  Ø NIPER JEE contains 200 Questions for 2 hours (36 sec per question)
§  Ø Most of the basic questions are asked in exam so there is no need to do much hard work but smart work
§  Ø The student has to move fast with adequate time for thinking on the question.
§  Ø Confidence, Self control, thinking capability and hard working are the essential requirements to be successful in exam.
§  Ø NIPER has its own merit (so don’t think much on GPAT rank).
§  Ø Generally for all NIPERs admission closes on below 500 rank
So in order to give an essential thrust to your dream, I am providing a kind of near to exam point of view syllabus for aspirants (Although NIPER exam don’t have any syllabus, you have to read everything) and ya this syllabus is acroding to what me and my other NIPER friends read and not authorized. So if any descrepeniency arises, you can refer if you know much than this..!!

Subject Wise

 1.     Pharmaceutics: Leon Lachman is the most widely used book and most referred for exam. Do all the chapters, starting from Milling, mixing to semisolid dosage forms. All the tables of Lachman are important. Questions will be mostly from Lachman.

Chapters: Milling, Mixing, Size reduction and separation, Drying, Filtration, Aerosols, Sterilizations, Suspension, Emulsion, Parenterals, Micro-encapsulation, Semisolids, Suppositories, compression and Consolidation, Tablets, Capsules, Coating, Liquid dosage forms, Preformulation etc.

Martin/Subramanyam: Subramanyam should be referred for all chapters. However, States of matter and last 2 chapters should be referred from Martin.

Brahmankar: Read this book very cautiously as there is many questions prone to come from this book
ADME chapters, Nonlinear Pharmacokinetics, Compartment modelling (all methods like Wegner Nelson, Residual method, Loo Reigelman, NDDS, All equation of AUC, Tmax, Cmax, Clearance etc.

Read all dose calculations formula from RM Mehta.

Cosmetics: Read essential ingredients of each cosmetic formulation and their use.2.    


2. Pharmacology: Rang and Dale

-         Tables and boxes of each chapter, bold letter points from book. Initial chapters are very important from the book like receptors, signal transduction. Everything should be known about receptors. Mechanism of action of drugs, classification (Refer KDT also for this), adverse effects, Specific use, haematology, vaccines etc from K.D. Tripathi

-         Receptor- theories, type: spare, silent, orphan, pre & post synaptic.
-          Concept of CGMP, CAMP, desensitization, tachyphylaxis , drug dependence .drug interaction.
-         . Detail study –antimalarial, anti TB, antileishmanial, anti-diabetic bioassay


3.     Organic Chemistry

-Stereochemistry (from all 3 books – Brahmankar, Morrison and Jerry March)

- Concepts like hybridization, inductive effect, hyper conjugation, resonance, acidity and basicity comparison between heterocyclic’s, aliphatic and aromatics.
-         Name reactions (30-35)
-         Bio-molecules from Morrison-Boyd
-         Glossary from Mehta and Mehta
-         Name and formula of all the catalysts used in chemical processes
-          All the rules in chemistry (Markovnikov, Antimarkonikov, Bredt’s etc)
-         SN1,SN2,E1,E2, Huckel’s rule,
-         Ester Hydrolysis mechanism, tautomerism, pericyclic reactions, Diels Alder reaction.


 4.     Analysis:

§  Ø NMR (Kemp and Pavia): NMR values, standards, solve simple spectra’s, and instrumentation etc. Do read Ravishankar.
§  Mass Spectroscopy(Pavia)
§  Ø UV (Pavia)
§  Ø IR(Pavia)
Do read Kasture, Ravishankar and Chatwal for all chapters.
§  Ø AAS, Fluorimetry, Flame photometry etc. (Kasture, Ravishanakar, Chatwal)
§  Ø Chromatography (Kasture, Ravishanakar, Chatwal)
§  Ø Karl-Fischer
§  Ø Titrations
§  Ø DSC, TGA, XRD, FTIR
§  Ø Stability studies and its conditions and zones of stability

§  5.  Pharmacognosy: Kokate (all chapters including marine drugs)

Evans: Marine drugs, Quality control, Flavanoids, Caretenoids etc
Refer Khandelwal for tables of characteristics of imp drugs, chemical tests, and Microscopies (generally type of stomata, type of leaf is asked).

Biosynthetic Pathways, primary and secondary metabolites, Nutraceuticals, Plant growth regulators

6.     Biochemistry: All important chapters like Carbohydrates, protein, lipids, cell structure, vitamins, enzymes, nucleic acids, PCR, Porphyrins, metabolism cycles, Lac operon, biochemical values,  Biochemical Tests, Fermentation etc, industrial enzymes, vaccines and other biotech products, Electrophoresis.

7.     Microbiology: Bacterial cell wall, growth, Disease causing organisms from fungi, bacteria, Rickettssia etc, diagnostic tests, microbial assays, Hypersensitivity, Immunology, Virus, Industrially utilized organisms.

8.     IP: Blue pages in it, Solubility limits, temperature limits, Dissolution apparatus, limits of tablets, capsules, semisolids etc


What’s NEW????

 1.     General Knowledge: Read everyday news paper. Remember current happenings like Miss INDIA, Miss World peagent, Olympic Games will be held at?
IPL Team  Owners

2.     Pharmaceutical News: Subscribe to Fierce pharmaceutical mails, Read pharmaceutical news from Economic times or another site from web.

3.     Nobel Prize winners: Name and his work. Recent award getters and all Indian Noble prize winners and their area.

4.     New Drugs approvals: Read the drugs approved in last 3 months and their use from USFDA site.

5.     Regulatory: Read some guidelines and like 505b2 (Hybrid NDA), 505b1 etc.

6.     New Drug application (NDA), Abbreviated New Drug Application (ANDA), Supplementary NDA, Emergency NDA, Treatment NDA

7.     Intellectual Property Rights: Patents, Copyrights, Trademarks etc. Fees for patents, duration, time for processing for patent, provisional patent, WIPO, TRIPS, Mail-box applications, Orange book, Hatch-Waxman Act, Para 1,2,3, 4 and what are they used for, compulsory licence, Transfer of Technology and Capture of Technology, TRIMS, Patent Organization Treaty etc.

8.     Full forms

 9.     Synonyms/Antonyms/ Vocabulary

 10.   Biostatistics: Mean, Median, Mode, Standard deviation, Correlation coefficients, confidence intervals, Probability, Permutation and combination, ANOVA (use, definition and formula), t-test (Use, definition and formula) etc.

11.  Amorphous systems: Definition, methods for amorphous generation, Glass transition (Tg), vitrification, devitrification, Methods for Tg determination etc.

12.  Jurisprudence: Schedules, Members in committee, places of institutes, important years related to Act and laws in pharmacy.

13.  Bank: various banks in INDIA, their CEO’s, their year of establishment and other information

14.  World Regulatory agencies of various countries: INDIA (CDCSCO), ANVISA (Brazil), TGA (Australia), FDA (USA), EMEA (Europe).

15.  Gene sequencing, Alignment tools etc.

 16.  Stages of formulation development

17.  Basic knowledge about NABARD, Planning commission etc.

18.  Symbols for amino acids

19.  Top 10 pharmaceutical companies in India and World

20.  Softwares

21. Refer all previous years papers