Pharmacology Mnemonics:

Pharmacology Mnemonics:

**Morphine: side-effects MORPHINE:

Myosis

Out of it (sedation)

Respiratory depression

Pneumonia (aspiration)

Hypotension

Infrequency (constipation, urinary retention)

Nausea

Emesis

**Adrenoceptors: vasomotor function of alpha vs. beta

ABCD:

Alpha = Constrict.

Beta = Dilate.


**Antirheumatic agents (disease modifying): members

CHAMP:

Cyclophosphamide

Hydroxycloroquine and choloroquinine

Auranofin and other gold compounds

Methotrexate

Penicillamine

**Phenytoin: adverse effects PHENYTOIN:

P-450 interactions

Hirsutism

Enlarged gums

Nystagmus

Yellow-browning of skin

Teratogenicity

Osteomalacia

Interference with B12 metabolism (hence anemia)

Neuropathies: vertigo, ataxia, and headache

Time table for GPAT 2013

 Time table for GPAT: 

1, Pharmaceutics: Lachman imp chapters and tables: (5 days), Subramaniam Physical Pharmacy (2 days-small book), Brahmankar (2 days), Posology,latin names and incompatability (1 day) - 10 days.
2.Pharmacology: Al mechanisms, imp Adv effects, interactions, specific use, contraindications, receptors from dale, vaccines,anticancer and classfications from KDT
3.Analysis: spectroscopy (chatwal/ravishankar and kasture), Titrations (ravishankar and kasture), Chromatography (Chatwal, Ravishankar and kasture + remington) and TGA,DTA,karlfisher, DSC, XRD etc- 7 days4.Indian pharmacoepia: imp pages:1 day
5.Chemsitry: MEd chem: structures of imp drugs, chemical classification, SAR of imp rings, starting materials of imp drugs,active isomers of drugs, QSAR and molecular modelling,IUPAc-5 days
Org chemistry: Stereochemistry, Names reactions, name of catalysts, general concepts like SN1, SN2, E1 E2 E1cB rxns, carbocations, anions,nitrenes, free radicals, protein carbohydrate and lipid chpaters from Morrison, Glossary of mehta and mehta -5 days, Mehta and Mehta book glossary
6. Pcognosy: Kokate + microscopy from khandelwal and Quality control from evans, do carotenoids, flavonoids from any good book 7 days
7. Biochem: All imp chapters from satyanarayn , Cycles, Genetics like DNA replication, purification, Protein synthesis,PCR, Lac operon, Hb synthesis, Amino acid cycles, biochemical tests- 5 days
8. Micro: Kokare whole book + Fermentaion from other books like Satyanarayan or kokare Biotechnolgy book - 5 days
9. Theory from Any good book like Piyush or BET and GPAT

Do complete every day one paper with theory from Inamdar book. arrange 20 days in this way for 20 papers

DRUGS BANNED IN INDIA

DRUGS BANNED IN INDIA

Tetracycline liquid oral suspension

Penicillin skin/eye ointement

Methaquinone

Oxytetracycline liquid oral preperations

Demeclocycline liquid oral preperations

Rosiglitazone

Astemizole

Terfinadine

DNA technology

VECTOR used in r DNA technology...
Previously = E.coli

Recently = B.subtilis

t-test = used to compare two experimental means with known values or sets of pairs of experiment values.

f- test = enables the precisions of two sets of data to be compared using their variance.

Q-test = used to determine whether to reject or retain suspected outliner...

ANNOVA = several sets of data to assess & compare different sources of variability.....

TABLET EVALUATION

MEMORIZER

TABLET EVALUATION

1 Size & thickness = -/+ 5 %

2 UNique identification marking,

3 Organoleptic marking = colour ,taste , odour apperance

COLOUR measured by

a reflectance spectrometer
b tristimulus colorimetery
c micro reflectancemeter

4 Hardness & Friability hardness instrument...a mosanto tester
b erweka tester
c strong & cobb tester
d schleuniger
e pfizer

Friability = 0.5 - 1 % roche friabilator

5 weight variation ....20 tab are tested acc to USP NMT 2 outside the limit

NMT 2 times of the % limit.

acc to IP less then 85mg +/_ 10%
85mg-250mg +/_ 7.5%
greater than 250mg +/_ 5%

6 Disintegration temp 37+/_ 2 C
6 tubes 3 inch long 10 mesh size

28-32 cycles /min

uncoated =5 min , coated = 30min

enteric in gastric like fluid no sign of disintegration in 1 hr

& in intestinal like fluid 2hrs plus moograph value

7 dissolution test...