Pharma Experts: March 2013

Wednesday 27 March 2013

Pharmacology Mnemonics:

Pharmacology Mnemonics:

**Morphine: side-effects MORPHINE:

Myosis

Out of it (sedation)

Respiratory depression

Pneumonia (aspiration)

Hypotension

Infrequency (constipation, urinary retention)

Nausea

Emesis

**Adrenoceptors: vasomotor function of alpha vs. beta

ABCD:

Alpha = Constrict.

Beta = Dilate.

**Antirheumatic agents (disease modifying): members

CHAMP:

Cyclophosphamide

Hydroxycloroquine and choloroquinine

Auranofin and other gold compounds

Methotrexate

Penicillamine

**Phenytoin: adverse effects PHENYTOIN:

P-450 interactions

Hirsutism

Enlarged gums

Nystagmus

Yellow-browning of skin

Teratogenicity

Osteomalacia

Interference with B12 metabolism (hence anemia)

Neuropathies: vertigo, ataxia, and headache

Time table for GPAT 2013

Time table for GPAT:

1, Pharmaceutics: Lachman imp chapters and tables: (5 days), Subramaniam Physical Pharmacy (2 days-small book), Brahmankar (2 days), Posology,latin names and incompatability (1 day) - 10 days.
2.Pharmacology: Al mechanisms, imp Adv effects, interactions, specific use, contraindications, receptors from dale, vaccines,anticancer and classfications from KDT
3.Analysis: spectroscopy (chatwal/ravishankar and kasture), Titrations (ravishankar and kasture), Chromatography (Chatwal, Ravishankar and kasture + remington) and TGA,DTA,karlfisher, DSC, XRD etc- 7 days4.Indian pharmacoepia: imp pages:1 day
5.Chemsitry: MEd chem: structures of imp drugs, chemical classification, SAR of imp rings, starting materials of imp drugs,active isomers of drugs, QSAR and molecular modelling,IUPAc-5 days
Org chemistry: Stereochemistry, Names reactions, name of catalysts, general concepts like SN1, SN2, E1 E2 E1cB rxns, carbocations, anions,nitrenes, free radicals, protein carbohydrate and lipid chpaters from Morrison, Glossary of mehta and mehta -5 days, Mehta and Mehta book glossary
6. Pcognosy: Kokate + microscopy from khandelwal and Quality control from evans, do carotenoids, flavonoids from any good book 7 days
7. Biochem: All imp chapters from satyanarayn , Cycles, Genetics like DNA replication, purification, Protein synthesis,PCR, Lac operon, Hb synthesis, Amino acid cycles, biochemical tests- 5 days
8. Micro: Kokare whole book + Fermentaion from other books like Satyanarayan or kokare Biotechnolgy book - 5 days
9. Theory from Any good book like Piyush or BET and GPAT

Do complete every day one paper with theory from Inamdar book. arrange 20 days in this way for 20 papers

DRUGS BANNED IN INDIA

DRUGS BANNED IN INDIA

Tetracycline liquid oral suspension

Penicillin skin/eye ointement

Methaquinone

Oxytetracycline liquid oral preperations

Demeclocycline liquid oral preperations

Rosiglitazone

Astemizole

Terfinadine

DNA technology

VECTOR used in r DNA technology...
Previously = E.coli

Recently = B.subtilis

t-test = used to compare two experimental means with known values or sets of pairs of experiment values.

f- test = enables the precisions of two sets of data to be compared using their variance.

Q-test = used to determine whether to reject or retain suspected outliner...

ANNOVA = several sets of data to assess & compare different sources of variability.....

TABLET EVALUATION

MEMORIZER

TABLET EVALUATION

1 Size & thickness = -/+ 5 %

2 UNique identification marking,

3 Organoleptic marking = colour ,taste , odour apperance

COLOUR measured by

a reflectance spectrometer
b tristimulus colorimetery
c micro reflectancemeter

4 Hardness & Friability hardness instrument...a mosanto tester
b erweka tester
c strong & cobb tester
d schleuniger
e pfizer

Friability = 0.5 - 1 % roche friabilator

5 weight variation ....20 tab are tested acc to USP NMT 2 outside the limit

NMT 2 times of the % limit.

acc to IP less then 85mg +/_ 10%
85mg-250mg +/_ 7.5%
greater than 250mg +/_ 5%

6 Disintegration temp 37+/_ 2 C
6 tubes 3 inch long 10 mesh size

28-32 cycles /min

uncoated =5 min , coated = 30min

enteric in gastric like fluid no sign of disintegration in 1 hr

& in intestinal like fluid 2hrs plus moograph value

7 dissolution test...

Pharmaceutical chemistry. (PRE TEST)

1. Compostion of universal indicator ?

2. Which ismoer of metyrosin possesess the inhibitory activity ?

3. CH3 is meta or ortho director. Exaplin.

4. Name four adrenergic drugs with 2 amino imidazoline is their ring moeity .

5. What is Wij's method?

6.Formula for determining acid value.

7. In directly acting sympathomimetics increasing the alkyl chain size at the amine group will ______ theactivity at beta receptor.

8. Composition of barfoed reagent ?

9. Benzene + pyrimidine = _________ is the ring which will form.

10. What is a) active hydrogen b)anomeric carbon c) Mannich reaction d) Perkin reaction. Name any two drugs that undergoes oxidation at benzylic carbon.

PHARMACEUTICS. (PRE TEST)

1. What are these chemically. A) Tween 20. B) Span 80

2. Exapand DLVO. What is the significance of gold no.

3. Nitrocellulose in nail lacquer act as ________

4. Exaplain stokes law.

5. advantage of ubbelhode viscometer over ostwald viscometer.

6. What is zeta potential. Addition of electrolytes will ______ zeta potential.

7. Give two principal surfactants used in shampoos.

8. What is a) freeze drying b) Hatch choate equation c) kozency carman equation d) Bancroft rule

9. Define structured vehicle. Name three antioxidants used in suspensions.

10 Give three emulsifying bases used in suppositories.

PHARMACOLOGY ( PRE TEST)

1. I am giving furosemide to a hypercalciuric patient. Should i go on or immediately stop. Explain.

2. Name two potassium channel opener.

3. Arrange them in increasing order of potency

4. What is the QT segment. Should i give quinine to the person with QT prolongation ?

5. Which drug is used as natural antidepressent ..Name the active constituent in it.

6.Which antiepileptic drug is DOC in trigeminal neuralgia.

7. What is LP(a)?

8. Which first line drug used in TB is only bateriostatic and not cidal ?

9. Efavirenz limits HIV infection by _________

10. Loading dose of a drug depends upon volume of distribution. True or false. Explain ur answer.

PHARMACOGNOSY. (PRE TEST)

1. composition of A) Wagner's reagent b) Dragendroff's reagent. C) Haers reagent.

2. Biological source of A) Kurchi b ) Kalmegh c ) Lemon peel D) colocynth.

3. Microscopical feature which differentiate fennel from corainder ?

4. Ginger have septate fibres. True of false.

5. Sucralose is ______ imes sweeter than sucrose.

6. One of the main constituent of Nux vomica used as a stnadard for bitterness. Name it.

7. Define a ) Paracytic b) Anomocytic stomate. Gie example of each.

8. Difference between lenticels ,cicatrix, and stomata.

9. Borneol is the main constituent of ________

10 Synonym of American podophyllum is ______

GOVERNAMENT & REGULATORY BODIES OF PHARMA

A directory of links to pharmaceutical, medical and health-related government and regulatory bodies around the world.

International

Argentina

Wednesday 27 March 2013

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