GPAT Questions

GPAT QUESTION LIST :

1. Dissolution is affected by 

a. Surface area

b. Temperature

c. Viscosity

d. None of above

2. The first U.S.P was published in 

a. English and Spanish

b. English and Latin

c. English and French

d. French and Latin

3. Shrinkage of gel by extrusion of liquid is called 

a. Syneresis

b. Dilatancy

c. Plasticity

d. Ebullition

4. As per G.M.P. permitted limit of solid content in water for injection is 

a. 0.1 ppm

b. 1.0 ppm

c. 10 ppm

d. 100 ppm

5. In extemporaneous preparation of a suspension, levigation is used to, 

a. Reduced viscosity

b. Reduced zeta potential

c. Reduce particle size

d. Avoid bacterial growth

6. Bancroft rule is related with 

a. Solutions

b. Suspensions

c. Emulsions

d. Suppositories

7. How to calculate total V.P of the system? 

a. C = Ca + Cb

b. P = Pa + Pb

c. P = Pa + Pb (Pc)

d. P = Pa - Pb

8. Particle size of colloidal solution dispersion is, 

a. 1x 10-9 to 1x 10-4 mm

b. 1x 10-7 to 1x 10-5 mm

c. 1x 10-4 to 1x 10-1 mm

d. 1x 10-6 to 1x 10-3 mm

9. Which formula is used to calculate children’s dose of 2 years old 

a. Fried's formula

b. Bastedo's formula

c. Clark's formula

d. Dilling's formula

10. The vehicle used in progesterone injection B.P is 

a. Fixed oil

b. Lard

c. Glycerine

d. None of above

MEDICINAL CHEMISTRY:

1. Pyrimethacine is derivative of 

a. Pyridine

b. Pyrimidine

c. Acridine

d. None of above

2. Tolazoline is derivative of 

a. 4,5-diydroimidazole

b. 2-imidazolidinedione

c. 5-imidazole

d. Pyrazolidinedione

3. Oxyphencyclamine is synthesized from 

a. α-cyclohexyl-α-hydroxy-α-ph

enyl acetic acid

b. α-propionyl-p-chlorophenyl aceto nitrile

c. α-benzyl- α-methyl-p-hydroxy acetic acid

d. a & b

4. Pentetrazol contains, 

a. 4 membered ring

b. 4 double bonds

c. Azepine nucleus

d. Diazepine nucleus

5. Van Braun’s method for opening of tetracyclic amines involves treatment of compound with 

a. HCN

b. BrCN

c. ICI

d. CN-CH2-COOH

6. Reserpine on hydrolysis gives 

a. Reserpic acid + Methyl alcohol + Trimethoxycinnamic acid

b. Reserpic acid + Acetic acid + Trimethoxybenzaldehyde

c. Reserpic acid + Methyl alcohol + Trimethoxybenzoic acid

d. Reserpic acid + Methyl alcohol + Trimethoxycinnamaldehyde

7. The factors affecting diffusion current in polarography can be given by which of following, 

a. Nernst equation

b. Mark-Houwink equation

c. Lamberts law

d. Ilkovic equation

8. Thiotepa, a cytotoxic agent, is assay by titrating with 

a. HCl

b. HClO4

c. Na2S2O3

d. KMnO4

9. IUPAC name of Pethidine is, 

a. RS-dimethyl[1-phenyl-3-(phenot

hiazin-10-yl)propyl]amine

b. Ethyl-1-methyl-4-phenyl-piperi

dine-carboxylate

c. RS-1-isopropylamino-3-(1-nepht

hyloxy)-propon-2-ol

d. Propyl-4-carbamoylmethoxy-3-methoxy-phenyl acetate

10. The chemical reaction shown below can be carried out using following reagent,

a. AlCl3

b. CuCl2

c. CH3COONa

d. CH3MgBr

PHARMACOLOGY:

1. Which one of this is not correct for levamisole? 

a. Can delay the hypersensitivity and T-cell mediated immunity

b. Used in Hodgkin’s disease and rheumatoid arthritis

c. Adjuvant chemotherapy for colorectal cancer

d. Used as a immuno suppressive agent

2. Plasmodial is resistant to chloroquine becase 

a. Increase in RNA polymerase

b. Decreased drug uptake

c. Bypass of DNA metabolism

d. Inhibition of oval formation

3. The anthelmintic drug acting by producing flaccid paralysis of worm 

a. Stilbophen

b. Mebendazole

c. Diethyl carbamazine

d. Piperazine

4. The most potent intracellular antikochs drug is 

a. Rifampacin

b. Nystatin

c. Ethambutol

d. Polymyxin

5. Toxicities of H2 antihistamines includes which one of following 

a. Diarrhea

b. P450 inibition

c. Blurred vision

d. Orthostatic hypotension

6. A 17 year old patient complains that he get severe shortens of breath whenever takes aspirin for headache. Increased level of which one of responsible for some cases of aspirin hypersensitivity? 

a. Misoprostol

b. Ibuprofen

c. Leucotriene C4

d. Alprastadil

7. The local anaesthetics having amide linkage differ from those having ester linkage in that the amide linked LAs. 

a. Are not surface anaestetics

b. Have a shorter duration of action

c. Are degraded in the plasma.

d. Do not show cross sensitivity with ester linked local anaesthetics.

8. In trigeminal neuroglia which of the following is used 

a. Imipramine

b. Phenytoin

c. Carbamazepine

d. Sodium valproate

9. Digitalis increased in RP of myocardial fibers is most consistent and pronounced in the 

a. A.V. node

b. Atria

c. Ventricles

d. Bundle of his

10. The diatery requirement of vit-B12 by an adult is 

a. 1-3 µg

b. 0.1-0.3 µg

c. 10-30 µg

d. 5-10 µg

ANALASYS:

1. The rate of movement of component R in column chromatography is given by, 

a. R = αAs/Am + aAs 

b. R = Am/Am + αAs

c. R = As/Am + As

d. R = Am/ αAs 

2. In isocratic elution technique, the ratio of petroleum ether and benzene should be in 

a. 1:2

b. 1:1

c. 2:1

d. 2:2

3. At ground state, the energy of a molecule is the sum of _____________energy 

a. Rotational + Vibrational

b. Vibrational + Electronic

c. Electronic + Rotational

d. All the three

4. Flame photometry, fluorimetry are examples for 

a. Emission spectroscopy

b. Absorption spectroscopy

c. Molecular spectroscopy

d. None of above

5. The wavelength in colorimetry ranges from 

a. 400-800 nm

b. 200-400 nm

c. 800-1200 nm

d. 1200-1500 nm

6. In spectrometers, the wavelength accuracy is given as, 

a. ± 0.01 nm

b. ± 10 nm

c. ± 1 nm

d. ± 0.1 nm

7. The E 1cm 1% for paracetamol at 257nm 

a. 835

b. 785

c. 715

d. 945

8. Digitoxin is analyzed by using which reagent 

a. Methanol

b. Alkaline picric acid

c. Ferric chloride

d. Phenyl hydrazine

9. Hydrogen discharge lamp consist of 

a. Hydrogen under pressure

b. Deuterium

c. Xenon

d. Mercury vapour

10. Absorbance and transmittance are 

a. Directly proportional

b. Inversely proportional

c. Linearly proportional

d. Not related

PHAMACOGNASY:

1. Oil of chenopodium is useful in 

a. Hook worm disease

b. Diarrhea

c. Cogh

d. Malaria

2. Salicin is alcoholic glycoside obtained from, 

a. Vanilla planifolia

b. Salix discolor

c. Salix purpurea

d. Prunes serotina

3. Wild cherry, oak, hammelis are the crude drugs which contain, 

a. Gallitannins

b. Catechol tannins

c. Pseudotannins

d. Ellagitannins

4. Flax seed is synonym for 

a. Cotton seed

b. Castor seed

c. Linseed

d. Rape seed

5. Color of oil is removed by heating it with 

a. Kaolin

b. Silica gel

c. Fuller's earth

d. Aluminium oxide

6. Dragondroff's reagent is prepared from: 

a. Na nitoprusside and iodine

b. Saturated picric acid solution

c. Saturated gelatin solutions.

d. KI and Bi nitrate

7. Kaolin mainly consist of, 

a. Magnesium silicate

b. Aluminium silicate

c. Magnesium phosphate

d. Aluminium phosphate

8. Which form of methanol occurs naturally 

a. + form

b. ± form

c. - form

d. Meso form

9. hyosciamine is generally used as 

a. HCl

b. HBr

c. HI

d. All 

10. Shark liver oil contains: 

a. Vit A

b. Vit B

c. Vit C

d. Vit D

BIO-CHEMISTRY CLINICAL PHARMACY:

1. α D-glucose + 112˚ + 525˚ 19˚ β D glucose.for glucose above represents 

a. optical isomerism

b. mtarotation

c. epimerization

d. D and L isomer

2. A vasodilating compound is produced by decarboxylation of amino acid 

a. Arginine

b. Aspartic acid

c. Glutamine

d. Histidine

3. Te enzyme which can add water to C=C or remove water to create a double bond without breaking of double bond is 

a. Hydratase

b. Hydroxylase

c. Hydrolase

d. Esterase

4. The vitamin required for synthesis of hydroxyproline is 

a. Vit-A

b. Vit-D 

c. Vit-C

d. Vit-K

5. during synthesis for porphyrins,synthesis of δ-aminolevulinic acid occurs in 

a. cytosol

b. Both a and b

c. Ribosomes 

d. mitochondria

6. In serum product of Ca x p (in mg/100ml) in children is normally 

a. 20

b. 30

c. 50

d. 60

7. Excess intake of cobalt for longer time leads to 

a. Polycythemia

b. Megaloblastic anaemia

c. Pernicious anaemia

d. Microcytic anaemia

8. The transketolase enzyme in the pentose phosphate pathway requires 

a. Penthothenic acid

b. Thiamine

c. Riboflavin

d. Nicotinic acid

9. In biosynthesis of cholesterol, the step which controls rate and locus of metabolic regulation is 

a. GPPFPP

b. Squalenelanosterol

c. HMG CO-Amevalonate

d. Lanosterol14-desmethyl lanosterol

10. conversion of deoxyuridine monophosphate to thymidine monophosphate is catalysed by enzyme 

a. ribonucleoside reductase

b. thymidylate synthtase

c. CTP synthetase

d. Orotidylic acid decarboxylase

FORENSIC PHARMACY:

1. Chloramphenicol comes under Schedule 

a. G

b. H

c. W

d. P

2. Section-14 of factories act states that: 

a. Effective measures should be taken by employers to keep workroom free from dust and flame

b. A factory must be fenced by safeguard and substantial construction

c. Adequate arrangement should be made for running canteens and dispensary for employees

d. Aseptic environment should be maintained around the manufacture process.

3. Names from the register can be removed by only by an order of the: 

a. PCI

b. Register tribunal

c. Executive committee of PCI

d. Director of health service

4. Establishments which have a qualified person and engage in compounding of drug is: 

a. Drug store

b. Chemist and druggist

c. Pharmacy

d. Testing laboratories

5. Drugs for examination, test or analysis can be imported under license in form 

a. 10

b. 11

c. 12

d. 13

6. List of diseases that a drug should not claim to cure is given in schedule 

a. L

b. J

c. C

d. H

7. All shops and establishment are required to register with 

a. Central Government

b. Municipality

c. Commissioner

d. Chief inspector

8. List of minimum equipment necessary for running of pharmacy is given in schedule 

a. M

b. N

c. Q

d. R

9. Life period of drug is dealt in 

a. Q

b. R

c. P

d. T

10. The poison act passed in the year, 

a. 1857

b. 1919

c. 1948

d. 1971

MICROBIOLOGY:

1. The best medium for production of penicillin is 

a. Nutrient Agar

b. Corn steep liquor

c. Sulfite waste liquor

d. Whey

2. In streptococcus fecalis where the conjugation takes place 

a. pilli

b. cell membrane

c. cell wall

d. flagella

3. In Gm+ve and Gm-ve bacteria electron transport contain 

a. Naphthquinone

b. Plastoquinone

c. Ubiquinone

d. Both a and b

4. The genetic material in HIV is 

a. ds DNA

b. ss DNA

c. s DNA

d. none

5. Which one of the following act on replicating DNA 

a. Ethidium bromide

b. Nitrosogeranidine

c. Acridine orange

d. None of above

ANSWERS:

Pharmaceutics

1. b

2. b

3. a

4. d

5. c

6. c

7. b

8. d

9. a

10. d

Medi Chem

1. b

2. a

3. a

4. c

5. b

6. c

7. d

8. c

9. b

10. a

Pharmacology

1. d

2. b

3. d

4. a

5. b

6. c

7. d

8. c

9. a

10. a

Analysis

1. b

2. b

3. d

4. a

5. a

6. d

7. c

8. b

9. a10. b Pharmacognosy

1. a

2. c

3. b

4. c

5. c

6. d

7. b

8. b

9. b

10. a

Biochemistry

1. a

2. d

3. a

4. c

5. d

6. c

7. a

8. b

9. c

10. b

Forensic Pharmacy

1. b

2. a

3. c

4. c

5. b

6. b

7. a

8. b

9. c

10. d

Microbiology

1. b

2. c

3. a

4. a

5. c